Kháng nguyên Covid-19 (cập nhật đến 8/4/2022)

Kháng nguyên được hiểu đơn giản là những chất khi xâm nhập vào cơ thể con người thì sẽ được hệ thống miễn dịch nhận biết nhanh chóng và sinh ra các kháng thể tương ứng để kết hợp đặc hiệu với kháng nguyên ấy. Thông thường các kháng nguyên là một protein, một polysaccharide nhưng cũng có thể là bất cứ loại phân tử nào mang các hapten nhỏ gắn với một protein chuyên chở. Cục Thông tin khoa học và công nghệ quốc gia xin giới thiệu một số bài nghiên cứu đã được xuất bản chính thức và các bài viết được chấp nhận đăng trên những cơ sở dữ liệu học thuật chính thống. Những nghiên cứu công bố trước đó trong năm 2022 được tổng hợp tại đường link cuối bài. 


1. The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic.

Hoffmann M, Krüger N, Schulz S, Cossmann A, Rocha C, Kempf A, Nehlmeier I, Graichen L, Moldenhauer AS, Winkler MS, Lier M, Dopfer-Jablonka A, Jäck HM, Behrens GMN, Pöhlmann S.
Cell. 2022 Feb 3;185(3):447-456.e11. doi: 10.1016/j.cell.2021.12.032. Epub 2021 Dec 24.
PMID: 35026151

2. Antigen Test Positivity After COVID-19 Isolation - Yukon-Kuskokwim Delta Region, Alaska, January-February 2022.
Lefferts B, Blake I, Bruden D, Hagen MB, Hodges E, Kirking HL, Bates E, Hoeldt A, Lamont B, Saydah S, MacNeil A, Bruce MG, Plumb ID.
MMWR Morb Mortal Wkly Rep. 2022 Feb 25;71(8):293-298. doi: 10.15585/mmwr.mm7108a3.
PMID: 35202352

3. The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants.
Barrera-Avalos C, Luraschi R, Vallejos-Vidal E, Mella-Torres A, Hernández F, Figueroa M, Rioseco C, Valdés D, Imarai M, Acuña-Castillo C, Reyes-López FE, Sandino AM.
Front Public Health. 2022 Jan 3;9:780801. doi: 10.3389/fpubh.2021.780801. eCollection 2021.
PMID: 35047474


1. Effectiveness of rapid antigen testing for screening of asymptomatic individuals to limit the transmission of SARS-CoV-2: A rapid review

Kieran A. Walsh, Natasha Broderick, Susan Ahern, Christopher G. Fawsitt, Katie M. O’Brien, Marie Carrigan, Patricia Harrington, Michelle O’Neill, Susan M. Smith, Susan Spillane, Conor Teljeur, Máirín Ryan

Reviews in Medical Virology

First published: 29 March 2022

2. Utility of COVID-19 antigen testing in the emergency department

W. Frank Peacock MD, Karina M. Soto-Ruiz MD, Stacey L. House MD, PhD, Chad M. Cannon MD, Gary Headden MD, Brian Tiffany MD, PhD, Sergey Motov MD, Kian Merchant-Borna MPH, MBA, Anna Marie Chang MD, MSCE, Claire Pearson MD, MPH, Brian W. Patterson MD, MPH, Alan E. Jones MD, Joseph Miller MD, MS, Joseph Varon MD, Aveh Bastani MD, Carol Clark MD, MBA, Zubaid Rafique MD, Bory Kea MD, MCR, John Eppensteiner MD, James M. Williams DO, MS, Simon A. Mahler MD, MS, Brian E. Driver MD, Phyllis Hendry MD, Eugenia Quackenbush MD, David Robinson MD, MS, Jon W. Schrock MD, James P. D'Etienne MD, Christopher J. Hogan MD, Anwar Osborne MD, MPM, Ralph Riviello MD, MS, Stephen Young PhD, D

Journal of the American College of Emergency Physicians Open Volume 3, Issue 1

First published: 15 January 2022


1. Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study
Multiple Sclerosis and Related Disorders 24 January 2022 Volume 59 (Cover date: March 2022) Article 103560
Tobias Moser Ferdinand Otto Peter Wipfler

2. Diagnostic accuracy of rapid antigen test for COVID-19 in an emergency department
Diagnostic Microbiology and Infectious Disease16 January 2022 Volume 102, Issue 4 (Cover date: April 2022) Article 115635
Silvia Elli Francesco Blasi Giorgio Costantino

3. Rapid antigen test to identify COVID-19 infected patients with and without symptoms admitted to the Emergency Department
The American Journal of Emergency Medicine 22 October 2021 Volume 51 (Cover date: January 2022) Pages 92-97
Gianni Turcato Arian Zaboli Dietmar Ausserhofer

4. Endotheliopathy marked by high von Willebrand factor (vWF) antigen in COVID-19 is associated with poor outcome: a systematic review and meta-analysis
International Journal of Infectious Diseases 27 June 2021 Volume 117 (Cover date: April 2022) Pages 267-273
Arief Wibowo Raymond Pranata Januar Wibawa Martha

5. Evaluation of SARS-CoV-2 rapid antigen diagnostic tests for saliva samples
Heliyon 22 February 2022 Volume 8, Issue 2 (Cover date: February 2022) Article e08998
Marie Hagbom Noelia Carmona-Vicente Johan Nordgren

6. Surface plasmon resonance biosensor with laser heterodyne feedback for highly-sensitive and rapid detection of COVID-19 spike antigen
Biosensors and Bioelectronics 6 March 2022 Volume 206 (Cover date: 15 June 2022) Article 114163
Zongren Dai Xin Xu Yidong Tan

7. Clinical assessment of SARS-CoV-2 antigen rapid detection compared with RT-PCR assay for emerging variants at a high-throughput community testing site in Taiwan
International Journal of Infectious Diseases 26 November 2021 Volume 115 (Cover date: February 2022) Pages 30-34
Ming-Jr Jian Cherng-Lih Perng Hung-Sheng Shang

8. Evaluation of antigen-based rapid detection test for the diagnosis of SARS CoV-2 in low-income countries
Journal of Virological Methods 9 December 2021 Volume 300 (Cover date: February 2022) Article 114409
Toky Rakotomalala Randriamahazo Andry Maharo Andrianarivelo Andry Rasamindrakotroka

9. Synthetic nanobody-functionalized nanoparticles for accelerated development of rapid, accessible detection of viral antigens
Biosensors and Bioelectronics6 January 2022 Volume 202 (Cover date: 15 April 2022) Article 113971
Xiahui Chen Shoukai Kang Chao Wang

10. Assessment of the Abbott BinaxNOW SARS-CoV-2 rapid antigen test against viral variants of concern
iScience22 February 2022 Volume 25, Issue 3 (Cover date: 18 March 2022) Article 103968
Anuradha Rao Leda Bassit Wilbur A. Lam
11. CRISPR-Cas12a-mediated label-free electrochemical aptamer-based sensor for SARS-CoV-2 antigen detection
Bioelectrochemistry 19 March 2022 Volume 146 (Cover date: August 2022) Article 108105
Na Liu Ran Liu Jingjing Zhang

12. Performance of a high-throughput, automated enzyme immunoassay for the detection of SARS-CoV-2 antigen, including in viral “variants of concern”: Implications for clinical use
Journal of Clinical Virology 29 November 2021 Volume 146 (Cover date: January 2022) Article 105048
Slim Fourati Alexandre Soulier Jean-Michel Pawlotsky

13. Spike-based COVID-19 immunization increases antibodies to nucleocapsid antigen
Translational Research 25 October 2021 Volume 240 (Cover date: February 2022) Pages 26-32
Carlota Dobaño Alfons Jiménez Gemma Moncunill

14. The role of antigen-presenting cells in the pathogenesis of COVID-19
Pathology - Research and Practice 23 March 2022 Volume 233 (Cover date: May 2022) Article 153848
Rana Farzi Parisa Shiri Aghbash Hossein Bannazadeh Baghi

15. Bioactive hybrid metal-organic framework (MOF)-based nanosensors for optical detection of recombinant SARS-CoV-2 spike antigen
Science of The Total Environment 17 February 2022 Volume 825 (Cover date: 15 June 2022) Article 153902
Navid Rabiee Yousef Fatahi Mohammad Reza Saeb

16. Performance of anterior nares and tongue swabs for nucleic acid, Nucleocapsid, and Spike antigen testing for detecting SARS-CoV-2 against nasopharyngeal PCR and viral culture
International Journal of Infectious Diseases 9 February 2022 Volume 117 (Cover date: April 2022) Pages 287-294
Michalina A. Montaño Meagan J. Bemer Paul K. Drain

17. SARS-CoV-2 microfluidic antigen point-of-care testing in Emergency Room patients during COVID-19 pandemic
Journal of Virological Methods 20 October 2021 Volume 299 (Cover date: January 2022) Article 114337
Elisa Burdino Francesco Cerutti Valeria Ghisetti

18. Evaluation of the Roche-SD Biosensor rapid antigen test: Antigen is not reliable in detecting SARS-CoV-2 at the early stage of infection with respiratory symptoms
Diagnostic Microbiology and Infectious Disease 25 December 2021 Volume 102, Issue 4 (Cover date: April 2022) Article 115628
Heini Flinck Dominik Kerimov Janne Aittoniemi

19. Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
Clinics in Laboratory Medicine 3 November 2021 Volume 42, Issue 1 (Cover date: March 2022) Pages 97-109
Alana F. Ogata Roey Lazarovits David R. Walt
20. Diagnostic performance, user acceptability, and safety of unsupervised SARS-CoV-2 rapid antigen-detecting tests performed at home
International Journal of Infectious Diseases 14 January 2022 Volume 116 (Cover date: March 2022) Pages 358-364
Ida Johanne B. Møller Amalie R. Utke Sanne Jespersen

21. Highly sensitive and ultra-rapid antigen-based detection of SARS-CoV-2 using nanomechanical sensor platform
Biosensors and Bioelectronics 17 September 2021 Volume 195 (Cover date: 1 January 2022) Article 113647
Dilip Kumar Agarwal Vikas Nandwana Vinayak P. Dravid

22. Evaluation and clinical implications of the time to a positive results of antigen testing for SARS-CoV-2
Journal of Infection and Chemotherapy 10 November 2021 Volume 28, Issue 2 (Cover date: February 2022) Pages 248-251
Yusaku Akashi Yoshihiko Kiyasu Hiromichi Suzuki

23. Systematic profiling of antigen bias in humoral response against SARS-CoV-2
Virus Research 14 February 2022 Volume 312 (Cover date: 15 April 2022) Article 198711
Nana Wei Qiujing Wang Shibo Li

24. Detection of SARS-CoV-2 variants by Abbott molecular, antigen, and serological tests
Journal of Clinical Virology 20 January 2022 Volume 147 (Cover date: February 2022) Article 105080
Mary A Rodgers Ana Olivo Gavin A Cloherty

25. Quantum dots assembly enhanced and dual-antigen sandwich structured lateral flow immunoassay of SARS-CoV-2 antibody with simultaneously high sensitivity and specificity
Biosensors and Bioelectronics 17 November 2021 Volume 198 (Cover date: 15 February 2022) Article 113810
Jianghua Jia Lijiao Ao Jun Hu
26. Accuracy and ease-of-use of seven point-of-care SARS-CoV-2 antigen-detecting tests: A multi-centre clinical evaluation
eBioMedicine 24 December 2021 Volume 75 (Cover date: January 2022) Article 103774
Lisa J. Krüger Amilcar Tanuri Claudia M. Denkinger

27. The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants
Cell Host & Microbe 27 November 2021 Volume 30, Issue 1 (Cover date: 12 January 2022) Pages 53-68.e12
Chang Liu Daming Zhou Gavin R. Screaton

28. Electrochemical immunosensor for rapid and highly sensitive detection of SARS-CoV-2 antigen in the nasal sample
Talanta 5 January 2022 Volume 240 (Cover date: 1 April 2022) Article 123211
Mohammad Mehmandoust Z. Pinar Gumus Nevin Erk

29. Evaluation of serological anti-SARS-CoV-2 chemiluminescent immunoassays correlated to live virus neutralization test, for the detection of anti-RBD antibodies as a relevant alternative in COVID-19 large-scale neutralizing activity monitoring
Clinical Immunology 29 December 2021 Volume 234 (Cover date: January 2022) Article 108918
Antonio Cristiano Massimo Pieri Marzia Nuccetelli

30. Detailed epitope mapping of SARS-CoV-2 nucleoprotein reveals specific immunoresponse in cats and dogs housed with COVID-19 patients
Research in Veterinary Science 4 January 2022 Volume 143 (Cover date: March 2022) Pages 81-87
Barbara Colitti Francesco Bonfante Sergio Rosati

31. Association between FY*02N.01 and the severity of COVID-19: Initial observations
Hematology, Transfusion and Cell Therapy Available online 21 January 2022 In press, corrected proof
Marina C. A. V. Conrado Marcia R. Dezan Carla Luana Dinardo

32. Clinical sensitivity of rapid antigen test during a COVID-19 outbreak in Taipei, May to June 2021
Journal of the Formosan Medical Association Available online 28 March 2022 In press, journal pre-proof
Yung-Feng Yen Hsiao-Yun Hu Ya-Ling Lee

33. HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection
Current Opinion in Immunology Available online 25 March 2022 In press, journal pre-proof Article 102178
Danillo G. Augusto Jill A. Hollenbach

34. Different performance of three point-of-care SARS-CoV-2 antigen detection devices in symptomatic patients and close asymptomatic contacts: a real-life study
Clinical Microbiology and Infection Available online 21 February 2022 In press, corrected proof
Pilar Escribano Ana-Erika Sánchez-Pulido Jesús Guinea

35. Prospective evaluation of the point-of-care use of a rapid antigenic SARS-CoV-2 immunochromatographic test in a paediatric emergency department
Clinical Microbiology and Infection Available online 20 January 2022 In press, corrected proof
Quentin Ollier Sylvie Pillet Aymeric Cantais

36. Evaluation of the rapid antigen detection test STANDARD F COVID-19 Ag FIA for diagnosing SARS-CoV-2: Experience from an Emergency Department
Diagnostic Microbiology and Infectious DiseaseAvailable online 18 March 2022 In press, journal pre-proofArticle 115683
Sergio García-Fernández Daniel Pablo-Marcos Jorge Calvo

37. A prospective clinical evaluation of the diagnostic accuracy of the SARS-CoV-2 rapid antigen test using anterior nasal samples
Journal of Infection and Chemotherapy Available online 24 February 2022 In press, corrected proof
Yusaku Akashi Michiko Horie Hiromichi Suzuki

38. Rapid antigen assays for SARS-CoV-2: Promise and peril Clinics in Laboratory Medicine Available online 4 March 2022 In press, journal pre-proof Thao T. Truong Jennifer Dien Bard Susan M. Butler-Wu

39. Rapid antigen testing for SARS-CoV-2 infection in a university setting in Ireland: Learning from a 6-week pilot study
Public Health in Practice Available online 3 April 2022 In press, journal pre-proof Article 100255
Gerald Barry Catherine Mc CarneySimon J. More

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Nguồn: Cục Thông tin khoa học và công nghệ quốc gia, 8/4/2022